"Our findings contribute to a growing body of evidence that immune system dysfunction, including inflammation, may be involved in the pathophysiology of major psychiatric disorders...
"A new analysis of existing studies strongly supports the idea that there are increased levels of chemicals, called cytokines, in the body and brain that promote inflammation in individuals who are contemplating or have attempted suicide, even when compared to patients being treated for the same psychiatric disorders who are not suicidal.
"These cytokines are known to be involved in problems in other body organs, such as the joints (arthritis), the coronary arteries (atherosclerosis) and the lungs (asthma). Studies have long suggested that cytokines are released under conditions of psychological stress and that inflammation in the brain contributes to depression. Thus, the current study suggests that suicide emerges in the context of a relatively greater activation of the immune system than typical stress or depression."
high fat (42% fat, 43% carbohydrate (CHO),high sucrose (12% fat, 70% CHO (primarily sucrose)normal chow (13% kcal fat, 62% CHO) diets
*High sucrose diet altered more gut bacterial orders and genera than high fat.
*High sucrose diet impaired spatial memory and cognitive flexibility.
*Increased gut Clostridiales was associated with decreased cognitive flexibility.
*Decreased gut Bacteroidales was associated with decreased cognitive flexibility.