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Monday, April 13, 2015

Miscellaneous Research

Today’s post is a collection of things I’ve run into in research that I think are interesting and useful information in terms of wellness and aging.  I will give you a plain explanation first then cut and paste from the research.


1)  Since we’ve been talking about cancer, this first is about cancer.  The Warburg effect is the discovery that cancer only feeds on glucose.  Unlike your muscles which can switch to another fuel, cancer cells cannot.  This research found that short term fasting kills cancer cells.  It does so by depriving them of a way to generate energy for cell activities.  This is up and coming research and we’ll be hearing more about it.


Fasting induces anti-warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models


These findings indicate that the glucose and amino acid deficiency conditions imposed by STS (short term starvation) promote an anti-Warburg effect characterized by increased oxygen consumption but failure to generate ATP, resulting in oxidative damage and apoptosis.




New insight into the link between neurodegenerative disorders and inflammation has been gained by a new study that provides a framework to explore more fully the possibility that viral infection may lead to onset of these diseases.

3)  This one is easy to understand. 



Fewer than half of the physicians trained in the United States in 2013 received formal education or training on the subject of exercise, according to new research. "There are immense medical benefits to exercise; it can help as much as medicine to address some health concerns," said a national expert on the benefits of physical activity. "Because exercise has medicinal as well as other benefits, I was surprised that medical schools didn't spend more time on it."

4)  If you are insulin resistant…and the only way to really know is a fasting insulin test (not glucose)…this is very important information.  BTW, most people I know—even some thin ones are insulin resistant.  I was really pleased with what I learned about selenium and iodine, but magnesium is every bit as critical if not more so.  Like all minerals, if it’s not in the soil it doesn’t get into the plants. 

I go in for blood work next week and will have more to say about what minerals have done for me.  But one unexpected result of adding magnesium supplements is that of reduced incidence of getting up in the night to use the bathroom.  That’s a biggie for it means my sleep is better.


This study basically says that magnesium can prevent the transition from insulin resistance to type II diabetes because it reduces insulin resistance.  Take some.


Oral magnesium supplementation reduces insulin resistance in non-diabetic subjects - a double-blind, placebo-controlled, randomized trial.


The incidence of insulin resistance and metabolic syndrome correlates with the availability of magnesium (Mg). We studied the effect of oral Mg supplementation on insulin sensitivity and other characteristics of the metabolic syndrome in normomagnesemic, overweight, insulin resistant, non-diabetic subjects.. The results provide significant evidence that oral Mg supplementation improves insulin sensitivity even in normomagnesemic, overweight, non-diabetic subjects emphasizing the need for an early optimization of Mg status to prevent insulin resistance and subsequently type 2 diabetes.


5)  Along the same lines, the following from Diabetes Care, is self explanatory


In a 2011 controlled trial, vitamin K2 supplementation improved insulin sensitivity.


To summarize, we have demonstrated for the first time that vitamin K2 supplementation for 4 weeks increased insulin sensitivity in healthy young men.


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